Abstract
An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Antibodies, Viral / blood*
-
DNA, Viral / analysis
-
Hemophilia A / immunology
-
Hemophilia A / virology
-
Hepacivirus / chemistry
-
Hepacivirus / immunology*
-
Hepatitis C / immunology*
-
Humans
-
Immunocompromised Host / immunology*
-
Immunoenzyme Techniques
-
Kidney Failure, Chronic / immunology
-
Kidney Failure, Chronic / therapy
-
Kidney Failure, Chronic / virology
-
Molecular Sequence Data
-
Renal Dialysis
-
Viral Nonstructural Proteins / analysis
-
Viral Nonstructural Proteins / genetics
-
Viral Nonstructural Proteins / immunology
Substances
-
Antibodies, Viral
-
DNA, Viral
-
NS4 protein, hepatitis C virus
-
Viral Nonstructural Proteins
-
NS-5 protein, hepatitis C virus