Using single photon emission tomography (SPECT) and positron emission tomography (PET) to trace the distribution of muscarinic acetylcholine receptor (MACHR) binding radioligands

Life Sci. 1999;64(6-7):511-8. doi: 10.1016/s0024-3205(98)00595-5.

Abstract

Two [18F] labeled ligands for the mAChR were prepared and evaluated in rodents and nonhuman primates. The properties of both compounds, one an agonist and the other an antagonist, were consistent with M2 subtype specificity.

Publication types

  • Review

MeSH terms

  • Animals
  • Benzilates / metabolism*
  • Benzilates / pharmacokinetics
  • Brain / diagnostic imaging
  • Brain / metabolism
  • Fluorine Radioisotopes
  • Heart / diagnostic imaging
  • Humans
  • Ligands
  • Muscarinic Agonists / metabolism*
  • Muscarinic Agonists / pharmacokinetics
  • Muscarinic Antagonists / metabolism*
  • Muscarinic Antagonists / pharmacokinetics
  • Myocardium / metabolism
  • Physostigmine / metabolism
  • Pyridines / antagonists & inhibitors
  • Pyridines / metabolism*
  • Pyridines / pharmacokinetics
  • Quinuclidines / metabolism*
  • Quinuclidines / pharmacokinetics
  • Radioactive Tracers
  • Receptors, Muscarinic / metabolism*
  • Thiazoles / antagonists & inhibitors
  • Thiazoles / metabolism*
  • Thiazoles / pharmacokinetics
  • Tomography, Emission-Computed*
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Benzilates
  • Fluorine Radioisotopes
  • Ligands
  • Muscarinic Agonists
  • Muscarinic Antagonists
  • Pyridines
  • Quinuclidines
  • Radioactive Tracers
  • Receptors, Muscarinic
  • Thiazoles
  • 3-quinuclidinyl 4-fluoromethylbenzilate
  • Physostigmine
  • FP-TZTP