The purpose of this study is to prospectively determine the outcome of carotid duplex ultrasound screening in patients referred to a vascular surgeon for problems other than carotid disease. During a recent 12-month period, 307 patients age 65 years and older (mean 76 +/- 8 years) were referred to one vascular surgeon for problems other than cerebrovascular disease. Fifty-one percent of the patients were male, 49% were female, 32% were diabetic, 32% were hypertensive, 31% smoked, 20% had coronary artery disease, and 64% had peripheral arterial occlusive disease. All patients underwent a screening duplex ultrasound exam of the carotid arteries as approved by our Institutional Review Board. The results of our study showed that the prevalence of asymptomatic carotid artery stenosis >70% among patients seen by a vascular surgeon for problems other than cerebrovascular disease is high (21%) and is associated with male gender, advanced age, diabetes mellitus and having quit smoking. Continued carotid artery duplex screening is warranted in this patient population greater than age 65 years.