Abstract
We analyzed bone marrow and blood from human immunodeficiency virus type 1 (HIV-1)-infected individuals and described the HIV-1 quasispecies in these cellular compartments. HIV-1 isolates from the bone marrow of thrombocytopenic patients contained distinct amino acids in the V3 loop and infected T-cell lines, implicating this virus in the development of thrombocytopenia.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Bone Marrow / virology*
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Cell Line
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HIV Envelope Protein gp120
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HIV Infections / blood*
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HIV-1 / isolation & purification*
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Humans
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Molecular Sequence Data
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Sequence Alignment
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T-Lymphocytes / virology
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Thrombocytopenia / virology*
Substances
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HIV Envelope Protein gp120
Associated data
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GENBANK/AF094977
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GENBANK/AF094978
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GENBANK/AF094979
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GENBANK/AF094980
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GENBANK/AF094981
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GENBANK/AF094982
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GENBANK/AF094983
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GENBANK/AF094984
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GENBANK/AF094985
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GENBANK/AF094986
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GENBANK/AF094987
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GENBANK/AF094988
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GENBANK/AF094989
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GENBANK/AF094990
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GENBANK/AF094991
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GENBANK/AF094992
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GENBANK/AF094993
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GENBANK/AF094994
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GENBANK/AF094995
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GENBANK/AF094996
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GENBANK/AF094997
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GENBANK/AF094998
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GENBANK/AF094999
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GENBANK/AF095000
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GENBANK/AF095001
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GENBANK/AF095002
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GENBANK/AF095003
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GENBANK/AF095004
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GENBANK/AF095005
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GENBANK/AF095006