Abstract
7-Epiclusianone, isolated from Rheedia gardneriana, was tested in several biological assays. It was active in vitro against trypomastigotes of Trypanosoma cruzi but inactive in vivo in experimentally infected mice. It was also active against Artemia salina, but inactive against the fungus Cladosporium sphaerospermum and the snail Biomphalaria glabrata.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification
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Antiprotozoal Agents / pharmacology*
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Benzophenones
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Benzoquinones / chemistry
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Benzoquinones / isolation & purification
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Benzoquinones / pharmacology*
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Biomphalaria / drug effects
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Cladosporium / drug effects
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Decapoda / drug effects
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Mice
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Trees / chemistry*
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Trypanosoma cruzi / drug effects
Substances
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7-epiclusianone
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Antiprotozoal Agents
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Benzophenones
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Benzoquinones