Identification of mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with early-onset NIDDM and functional analysis of the mutant proteins

Diabetes. 1999 Mar;48(3):645-8. doi: 10.2337/diabetes.48.3.645.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Amino Acid Sequence
  • Amino Acid Substitution
  • DNA-Binding Proteins*
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetic Retinopathy / genetics
  • Female
  • Hepatocyte Nuclear Factor 1
  • Hepatocyte Nuclear Factor 1-alpha
  • Hepatocyte Nuclear Factor 1-beta
  • Humans
  • Japan
  • Male
  • Mutation, Missense*
  • Nuclear Proteins*
  • Pedigree
  • Point Mutation*
  • Polymerase Chain Reaction
  • Transcription Factors / genetics*
  • Transcriptional Activation

Substances

  • DNA-Binding Proteins
  • HNF1A protein, human
  • HNF1B protein, human
  • Hepatocyte Nuclear Factor 1-alpha
  • Nuclear Proteins
  • Transcription Factors
  • Hepatocyte Nuclear Factor 1
  • Hepatocyte Nuclear Factor 1-beta