Abstract
PCR-SSP was used to HLA-type a cohort of Ugandan HIV-positive individuals. The results represent a more comprehensive description of HLA in an African population than previously described and are in concordance with data from a general Black population. Substantial differences exist between this population and Caucasoid populations in which immunological responses to HIV have been investigated; this emphasises that the main HLA-restrictive elements for HIV-specific cytotoxic T lymphocytes will most likely be different for each population.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Base Sequence
-
DNA Primers
-
HIV Seropositivity / genetics*
-
HIV Seropositivity / immunology*
-
HLA-A Antigens / genetics
-
HLA-B Antigens / genetics
-
HLA-C Antigens / genetics
-
HLA-DQ Antigens / genetics*
-
HLA-DQ beta-Chains
-
HLA-DR Antigens / genetics*
-
HLA-DRB1 Chains
-
HLA-DRB3 Chains
-
HLA-DRB4 Chains
-
HLA-DRB5 Chains
-
Histocompatibility Antigens Class I / genetics*
-
Humans
-
Polymerase Chain Reaction / methods
-
Polymorphism, Genetic / immunology*
-
Uganda
-
Urban Population
Substances
-
DNA Primers
-
HLA-A Antigens
-
HLA-B Antigens
-
HLA-C Antigens
-
HLA-DQ Antigens
-
HLA-DQ beta-Chains
-
HLA-DQB1 antigen
-
HLA-DR Antigens
-
HLA-DRB1 Chains
-
HLA-DRB3 Chains
-
HLA-DRB4 Chains
-
HLA-DRB5 Chains
-
Histocompatibility Antigens Class I