Abstract
A double-blind, placebo-controlled Phase III cancer prevention trial in subjects with previous resection of adenomatous colon polyps is nearing completion. The study's primary objective is to evaluate the effects of daily dietary supplementation with large (13.5 g/day) versus small (2.0 g/day) doses of wheat bran fiber for 3 years. A summary of the study design and a progress report are presented.
Publication types
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Clinical Trial
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Clinical Trial, Phase III
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenomatous Polyposis Coli / diet therapy*
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Adenomatous Polyposis Coli / etiology
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Adenomatous Polyposis Coli / metabolism
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Adenomatous Polyposis Coli / prevention & control*
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Arizona
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Bile Acids and Salts / metabolism
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Dietary Fiber / administration & dosage*
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Double-Blind Method
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Humans
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Research Design
Substances
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Bile Acids and Salts
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Dietary Fiber