Abstract
Cafestol, a coffee diterpene present in unfiltered coffee brews, potently raises serum lipids in humans. The mechanism through which this dietary compound influences liporotein metabolism is largely unknown. Unravelling the mechanism of action might lead to new insights into the regulation of serum cholesterol levels in humans. This review summaries ways in which cafestol may act on serum lipids.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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CCAAT-Enhancer-Binding Proteins*
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Carrier Proteins / metabolism
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Cholesterol / blood*
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Cholesterol Ester Transfer Proteins
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Coffee / chemistry*
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DNA-Binding Proteins / metabolism
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Diterpenes / pharmacology*
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Glycoproteins*
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Humans
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Nuclear Proteins / metabolism
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Receptors, Cytoplasmic and Nuclear / metabolism
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors / metabolism
Substances
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CCAAT-Enhancer-Binding Proteins
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CETP protein, human
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Carrier Proteins
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Cholesterol Ester Transfer Proteins
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Coffee
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DNA-Binding Proteins
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Diterpenes
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Glycoproteins
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Nuclear Proteins
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Receptors, Cytoplasmic and Nuclear
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SREBF1 protein, human
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors
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Cholesterol
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cafestol