Preparation and properties of 2',5'-linked oligonucleotide analogues containing 3'-O,4'-C-methyleneribonucleosides

S Obika; K Morio; Y Hari; T Imanishi

doi:10.1016/s0960-894x(99)00028-1

Preparation and properties of 2',5'-linked oligonucleotide analogues containing 3'-O,4'-C-methyleneribonucleosides

Bioorg Med Chem Lett. 1999 Feb 22;9(4):515-8. doi: 10.1016/s0960-894x(99)00028-1.

Authors

S Obika¹, K Morio, Y Hari, T Imanishi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Japan.

PMID: 10098653
DOI: 10.1016/s0960-894x(99)00028-1

Abstract

Bicyclic nucleoside analogues, 3'-O,4'-C-methyleneuridine and -5-methyluridine, were successfully incorporated into oligonucleotides via connection with 2',5'-phosphodiester linkage, and hybridization behavior and nuclease stability of the modified oligonucleotides were investigated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Kinetics
Oligonucleotides / chemical synthesis
Oligonucleotides / chemistry*
Ribonucleosides / chemistry*

Substances

Oligonucleotides
Ribonucleosides