Wrist fractures (Colles) are one of the most frequently observed osteoporotic fractures in postmenopausal women. The aim of our study was the comparison of mechanical properties of distal radius of women with Colles fracture using a Stratec XCT 960 peripheral quantitative computed tomography (pQCT) in relation to age-pair controls without a wrist fracture. Using the pQCT method for estimation of SSI (Strength Strain Index), we found significant differences of SSI values in Colles subjects. In clinical practice, pQCT offers new diagnostic tools which cannot be provided by conventional densitometric methods.