MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response

R A Lake; B W Robinson; J D Hayball

doi:10.1046/j.1440-1711.1999.00794.x

MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response

Immunol Cell Biol. 1999 Feb;77(1):99-104. doi: 10.1046/j.1440-1711.1999.00794.x.

Authors

R A Lake¹, B W Robinson, J D Hayball

Affiliation

¹ University Department of Medicine, Queen Elizabeth II Medical School, Nedlands, Perth, Australia. [email protected]

PMID: 10101691
DOI: 10.1046/j.1440-1711.1999.00794.x

Abstract

Class II multimer formation is an important event in immune recognition. Not only is multimerization a prerequisite for T cell activation, but it is a signal to APC. In the present article, we propose that multimerization can result in the specific removal of ligand complexes from the cell surface of the APC, an event which may influence the overall pattern of T cell reactivity.

Publication types

Review

MeSH terms

Animals
Antigen-Presenting Cells / immunology*
Histocompatibility Antigens Class II / chemistry*
Histocompatibility Antigens Class II / metabolism
Humans
Ligands
Models, Biological
Protein Conformation
Receptors, Antigen, T-Cell / metabolism
Self Tolerance
T-Lymphocytes / immunology

Substances

Histocompatibility Antigens Class II
Ligands
Receptors, Antigen, T-Cell