Abstract
In germfree mice, the administration of short-chain fatty acids (SCFA) protected the intestinal mucosa from damage produced by 1-beta-D-arabinofuranosylcytosine (Ara-C). Animals receiving SCFA and Ara-C had intestinal morphologies closer to normal than the control animals, which had severe intestinal lesions. We concluded that orally administrated SCFA reduce intestinal lesions, improving the mucosa pattern of the small intestine and colon.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Administration, Oral
-
Animals
-
Cytarabine / adverse effects*
-
Disease Models, Animal
-
Fatty Acids, Volatile / adverse effects
-
Fatty Acids, Volatile / therapeutic use*
-
Fatty Liver / chemically induced
-
Intestinal Diseases / chemically induced
-
Intestinal Diseases / pathology
-
Intestinal Diseases / prevention & control*
-
Intestinal Mucosa / drug effects
-
Intestinal Mucosa / pathology
-
Mice
-
Protective Agents / adverse effects
-
Protective Agents / therapeutic use*
Substances
-
Fatty Acids, Volatile
-
Protective Agents
-
Cytarabine