Effects of 3alpha- and 3beta-galactosylated alpha-galactosylceramides on the immune system

Bioorg Med Chem Lett. 1999 Mar 8;9(5):697-702. doi: 10.1016/s0960-894x(99)00054-2.

Abstract

We compared effects of alpha-galactosylceramide (alpha-GalCer) and its 3alpha- or 3beta-galactosylated derivatives on the proliferation of murine spleen cells. The 3alpha-galactosylated alpha-GalCer showed stronger proliferative response than the parental alpha-GalCer, but the 3beta-galactosylated alpha-GalCer possessed weaker activity than the alpha-GalCer. In addition, alpha-Gal-3-Cer did not show immunostimulatory activity.

Publication types

  • Comparative Study

MeSH terms

  • Adjuvants, Immunologic / chemical synthesis
  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Cell Division / drug effects
  • Cell Division / immunology
  • Ceramides / chemical synthesis
  • Ceramides / pharmacology*
  • Dose-Response Relationship, Drug
  • Galactosylceramides / chemical synthesis
  • Galactosylceramides / pharmacology
  • Immune System / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Spleen / cytology
  • Spleen / drug effects*
  • Spleen / immunology

Substances

  • AGL 529
  • AGL 533
  • Adjuvants, Immunologic
  • Ceramides
  • Galactosylceramides