Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds

Z Y Yang; Y Xia; P Xia; Y Tachibana; K F Bastow; K H Lee

doi:10.1016/s0960-894x(99)00065-7

Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds

Bioorg Med Chem Lett. 1999 Mar 8;9(5):713-6. doi: 10.1016/s0960-894x(99)00065-7.

Authors

Z Y Yang¹, Y Xia, P Xia, Y Tachibana, K F Bastow, K H Lee

Affiliation

¹ Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360, USA.

PMID: 10201834
DOI: 10.1016/s0960-894x(99)00065-7

Abstract

Several substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-ones and related compounds were synthesized and evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines. The most active compound (3) showed significant cytotoxic activity with GI50 values in the micromolar range.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antineoplastic Agents / pharmacology*
Cell Division / drug effects
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Inhibitory Concentration 50
KB Cells
Pyrans / chemical synthesis*
Pyrans / pharmacology
Quinolines / chemical synthesis*
Quinolines / pharmacology
Tumor Cells, Cultured

Substances

8,8-dimethyl-2H,8H-pyrano(6,5-h)quinoline-2-one
Antineoplastic Agents
Pyrans
Quinolines

Grants and funding

CA 17625/CA/NCI NIH HHS/United States