Abstract
The NC 65 tumor cell line derived from human renal cell carcinoma was selected from among nine human cell lines by determining the inhibition of invasion by ND2001 (sodium D-glucaro-delta-lactam) in vitro. The efficacy of this agent against these tumor cells was investigated in an experimental metastatic model of human tumors in vivo. Although ND2001 did not inhibit growth of NC 65 cells intradermally transplanted into male KSN mice (nu/nu), this agent inhibited multiple spontaneous metastasis.
MeSH terms
-
Animals
-
Antineoplastic Agents / pharmacology*
-
Carcinoma, Renal Cell / drug therapy
-
Carcinoma, Renal Cell / secondary*
-
Colonic Neoplasms / pathology
-
Drug Screening Assays, Antitumor
-
Fibrosarcoma / pathology
-
Glucaric Acid / analogs & derivatives*
-
Glucaric Acid / pharmacology
-
Head and Neck Neoplasms / pathology
-
Humans
-
Kidney Neoplasms / drug therapy*
-
Kidney Neoplasms / pathology
-
Lung Neoplasms / drug therapy*
-
Lung Neoplasms / secondary*
-
Lymphatic Metastasis / prevention & control
-
Male
-
Melanoma / pathology
-
Mice
-
Mice, Inbred Strains
-
Mice, Nude
-
Neoplasm Invasiveness
-
Neoplasm Transplantation
-
Tumor Cells, Cultured / transplantation
Substances
-
Antineoplastic Agents
-
D-glucaro-delta-lactam
-
Glucaric Acid