[Identification and quantification of exogenous metabolites in biological liquids with new development in NMR spectroscopy in one and two dimensions]

Acta Clin Belg. 1999:53 Suppl 1:97-100.
[Article in French]

Abstract

By comparison of urine 1H NMR spectrum from a healthy person with those from poisoned patient, we have displayed one or several signals related to intoxication. In complement, various 1H and 13C NMR sequences in 1 and 2 dimensions (J-resolved, TOCSY, HMBC) were used to identify xenobiotic metabolites and quantify them in urine from patients poisoned with salicylate acetyl, chloroquine, valproïc acid, ethylene glycol and pesticides. NMR techniques provide a rapid determination on a small sample volume without pretreatment.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Analgesics / poisoning
  • Anticonvulsants / poisoning
  • Antimalarials / poisoning
  • Aspirin / analogs & derivatives
  • Aspirin / poisoning
  • Chloroquine / poisoning
  • Female
  • Humans
  • Lysine / analogs & derivatives
  • Lysine / poisoning
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Poisoning / diagnosis*
  • Poisoning / metabolism
  • Poisoning / urine*
  • Reproducibility of Results
  • Valproic Acid / poisoning

Substances

  • Analgesics
  • Anticonvulsants
  • Antimalarials
  • Valproic Acid
  • Chloroquine
  • Lysine
  • Aspirin
  • acetylsalicylic acid lysinate