10'-Hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis

M Frédérich; M Tits; M P Hayette; V Brandt; J Penelle; P DeMol; G Llabrès; L Angenot

doi:10.1021/np980375m

10'-Hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis

J Nat Prod. 1999 Apr;62(4):619-21. doi: 10.1021/np980375m.

Authors

M Frédérich¹, M Tits, M P Hayette, V Brandt, J Penelle, P DeMol, G Llabrès, L Angenot

Affiliation

¹ Laboratory of Pharmacognosy, Institute of Pharmacy, University of Liège, CHU, Tour 4, Avenue de l'Hôpital 1, B-4000 Liège, Belgium. [email protected]

PMID: 10217724
DOI: 10.1021/np980375m

Abstract

Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods. Compound 1 was moderately active against two strains of Plasmodium falciparum in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Animals
Antimalarials / chemistry
Antimalarials / isolation & purification
Antimalarials / pharmacology*
Humans
In Vitro Techniques
Indoles / chemistry
Indoles / isolation & purification
Indoles / pharmacology*
Magnetic Resonance Spectroscopy
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Plasmodium falciparum / drug effects
Rwanda
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tanzania

Substances

10'-hydroxyusambarensine
Alkaloids
Antimalarials
Indoles