Citicoline is an investigational new drug in this country that was provided on a compassionate use basis in two cases of traumatic brain injury after horseback riding accidents. While this report is primarily anecdotal, the behavioral observations in both cases suggested atypical patterns of improvement and perhaps greater recovery than might otherwise have been predicted. The side effect profile of this drug is negligible and previous experimental research has yielded positive findings for treatment after stroke and head trauma, as well as memory loss in aging. Consequently, Citicoline may potentially be very helpful for patients suffering traumatic brain injuries and should, in our opinion, be made available and studied further in this clinical population.