HIV combination therapy: immune restitution causing cryptococcal lymphadenitis dramatically improved by anti-inflammatory therapy

P Blanche; B Gombert; C Ginsburg; A Passeron; I Stubei; A Rigolet; D Salmon; D Sicard

doi:10.1080/00365549850161223

HIV combination therapy: immune restitution causing cryptococcal lymphadenitis dramatically improved by anti-inflammatory therapy

Scand J Infect Dis. 1998;30(6):615-6. doi: 10.1080/00365549850161223.

Authors

P Blanche¹, B Gombert, C Ginsburg, A Passeron, I Stubei, A Rigolet, D Salmon, D Sicard

Affiliation

¹ Service de Médecine Interne 2, Hôpital Cochin, Université René Descartes, Paris, France.

PMID: 10225395
DOI: 10.1080/00365549850161223

Abstract

Two patients with AIDS developed microscopically verified focal cryptococcal lymphadenitis while treated with highly active anti-retroviral therapy for 8 and 15 months. Both were treated with fluconazole as a secondary prophylaxis for prior cryptococcal meningitis. Cryptococcus neoformans did not grow. Amphotericin was ineffective. Anti-inflammatory drugs had a dramatic effect.

Publication types

Case Reports

MeSH terms

Acquired Immunodeficiency Syndrome / drug therapy*
Acquired Immunodeficiency Syndrome / immunology
Adult
Anti-Inflammatory Agents / therapeutic use*
Cryptococcosis / drug therapy
Cryptococcosis / etiology*
Fluconazole / therapeutic use
HIV Protease Inhibitors / therapeutic use*
Humans
Lymphadenitis / drug therapy
Lymphadenitis / etiology*
Male

Substances

Anti-Inflammatory Agents
HIV Protease Inhibitors
Fluconazole