Drug-induced pseudoporphyria cutanea tarda has been attributed to many different medications including several nonsteroidal anti-inflammatory drugs (NSAIDs). Often the patients taking these anti-inflammatory medications became part of a treatment dilemma when one of the drugs is deemed the cause of a blistering disease. We present a prototypical case of NSAID-induced pseudoporphyria cutanea tarda and suggest alternative NSAIDs that may be safely used in these patients.