Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease

Scand J Rheumatol. 1999;28(2):117-9. doi: 10.1080/030097499442595.

Abstract

Only few cases of Behçet's and hematological malignancies have been reported until now. We recently observed a 39-year-old female patient with Behçet's disease developing a myelodysplastic syndrome (MDS) FAB subtype refractory anemia with excess of blasts in transformation [RAEB-t] with a monosomy 7 after being treated with cyclosporin A and chlorambucil for several years. This case is reported and the occurrence of hematological malignancies and Behçet's disease is reviewed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Behcet Syndrome / drug therapy*
  • Behcet Syndrome / immunology
  • Behcet Syndrome / pathology
  • Bone Marrow Cells
  • Chlorambucil / administration & dosage
  • Chromosomes, Human, Pair 7*
  • Cyclosporine / administration & dosage
  • Fatal Outcome
  • Female
  • Humans
  • Immunosuppression Therapy
  • Immunosuppressive Agents / administration & dosage
  • Monosomy / pathology*
  • Myelodysplastic Syndromes / drug therapy*
  • Myelodysplastic Syndromes / immunology
  • Myelodysplastic Syndromes / pathology

Substances

  • Antineoplastic Agents, Alkylating
  • Immunosuppressive Agents
  • Chlorambucil
  • Cyclosporine