Synthesis, analysis and in vitro antibacterial activity of new metal complexes of sulbactam

I P Kostova; L S Changov; E E Keuleyan; R T Gergova; I I Manolov

doi:10.1016/s0014-827x(98)00092-5

Synthesis, analysis and in vitro antibacterial activity of new metal complexes of sulbactam

Farmaco. 1998 Dec 30;53(12):737-40. doi: 10.1016/s0014-827x(98)00092-5.

Authors

I P Kostova¹, L S Changov, E E Keuleyan, R T Gergova, I I Manolov

Affiliation

¹ Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.

PMID: 10230054
DOI: 10.1016/s0014-827x(98)00092-5

Abstract

Complexes of copper(II), nickel(II) and iron(III) with beta-lactamase inhibitor sulbactam have been synthesized, characterized and identified by elemental analysis, IR and 1H NMR spectroscopy. These complexes have been then tested for their in vitro antibacterial activity in combination with ampicillin against various bacterial species.

MeSH terms

Ampicillin / pharmacology
Anti-Bacterial Agents / analysis
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects*
Copper
Fungi / drug effects
Iron
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Nickel
Spectrophotometry, Infrared
Sulbactam / analogs & derivatives*
Sulbactam / analysis
Sulbactam / pharmacology*

Substances

Anti-Bacterial Agents
Copper
Ampicillin
Nickel
Iron
Sulbactam