Effect of renal transplantation (surgical stress) on serum levels of oxidants and reducing system

Panminerva Med. 1999 Mar;41(1):31-4.

Abstract

Background: This study attempts to understand the correlation (if any) between surgical stress of renal transplantation and serum levels of pro-oxidant/antioxidants.

Methods: Twenty-four ESRD patients having undergone transplant surgery followed from day-1 to day-10 postsurgery were investigated for serum levels of MDA, SOD, Vit. C and E. The drug regimen received was immunosuppressant, H2 blockers and antihypertensives as per the situation.

Results: The typical observations indicated elevated serum levels of MDA from preoperative stage reaching peak value 24 hrs after surgery followed by a steady fall and achieving minima on the 10th day. As regards antioxidants enzyme SOD, Vit. C, Vit. E were low from pretransplant day reaching minima 24 hours postoperatively and returning to normal from 7th day.

Conclusions: The present investigation has amply shown a typical imbalance between pro-oxidant/antioxidants from pretransplant day up to 24 hrs and there after returning to normal level from 7th day suggestive to desired recovery and surgical stress not a limiting factor in way of health progress renal transplant. Dietary intake of Vit. C and E in mega doses can be a good therapeutic measure.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Antioxidants / metabolism*
  • Humans
  • Kidney Transplantation*
  • Oxidants / blood*
  • Oxidation-Reduction
  • Stress, Physiological / blood*

Substances

  • Antioxidants
  • Oxidants