Hypermutation in antibody affinity maturation

Curr Opin Immunol. 1999 Apr;11(2):186-9. doi: 10.1016/s0952-7915(99)80031-4.

Abstract

By studying the role of mismatch repair in hypermutation at the immunoglobulin loci, the field of antibody hypermutation has been integrated into the larger area of DNA repair. Trans-acting factors - Ku70, Ku80 and possibly SWAP-70 - have been identified for the temporally related but not mechanistically related immunoglobulin heavy-chain class-switch.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibody Affinity*
  • DNA Repair*
  • Genes, Immunoglobulin*
  • Humans
  • Immunoglobulin Class Switching
  • Immunoglobulin Heavy Chains / genetics
  • Mutation*

Substances

  • Immunoglobulin Heavy Chains