Abstract
The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alphabeta lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of alphabeta lineage cells but also controls TCRbeta allelic exclusion as well as commitment to the gammadelta lineage versus the alphabeta lineage.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alleles
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Animals
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Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
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Humans
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Mice
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Protein Precursors / physiology*
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, alpha-beta / physiology*
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Receptors, Antigen, T-Cell, gamma-delta / physiology*
Substances
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Protein Precursors
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, gamma-delta