Abstract
Twelve children born to hepatitis C virus antibody GBV-C/HGV RNA positive mothers who acquired GBV-C/HGV infection by the vertical or perinatal route were studied. Most (91%) were persistently GBV-C/HGV RNA positive up to 12 months of age. Four out of six cases who acquired GBV-C/HGV alone had normal alanine amino transferase activities. Long lasting evidence of hepatocellular injury was detected only in children with GBV-C/HGV and hepatitis C virus and HIV coinfection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Flaviviridae* / genetics
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Follow-Up Studies
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HIV Infections / complications
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HIV Infections / pathology
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HIV Infections / transmission
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Hepatitis C / complications
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Hepatitis C / pathology
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Hepatitis C / transmission
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Hepatitis, Viral, Human / complications
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Hepatitis, Viral, Human / pathology
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Hepatitis, Viral, Human / transmission*
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Humans
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Infant
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Infant, Newborn
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Infectious Disease Transmission, Vertical*
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Liver / pathology
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RNA, Viral / blood
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Reverse Transcriptase Polymerase Chain Reaction