In patients with coronary bypass which utilizes left (LIMA) or right internal mammary artery (RIMA), recurrent ischemia is often due to stenosis of the distal anastomoses of the grafts. However, occasionally, ischemia may be due to extracoronary causes, such as subclavian disease proximal to the internal mammary artery origins. This case report describes such clinical situation emphasizing the need for careful patient evaluation, and discusses therapeutic interventional options, in particular, safety and effectiveness of self expanding subclavian stent implantation. A review of the literature is also presented.