Abstract
To determine the site of latent infection of canine herpesvirus (CHV), tissues from dogs convalescent from acute infection with CHV were examined for the presence of viral genome DNA by the nested polymerase chain reaction. CHV DNA was detected in the trigeminal ganglia and the retropharyngeal lymph nodes. In situ hybridization study of the tissues revealed that CHV genome persisted in the nuclei of ganglionic neurons and lymphocytes.
MeSH terms
-
Animals
-
DNA, Viral / analysis*
-
Dog Diseases / pathology
-
Dog Diseases / virology*
-
Dogs
-
Herpesviridae Infections / pathology
-
Herpesviridae Infections / veterinary*
-
Herpesviridae Infections / virology
-
Herpesvirus 1, Canid / genetics*
-
In Situ Hybridization / veterinary
-
Lymph Nodes / virology*
-
Lymphocytes / virology*
-
Neurons / virology*
-
Polymerase Chain Reaction / veterinary
-
Trigeminal Ganglion / virology*
-
Virus Latency