HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1

Cytogenet Cell Genet. 1999;84(1-2):115-7. doi: 10.1159/000015234.

Abstract

HOX11L1 is a homeobox gene involved in peripheral nervous system development as confirmed by knockout mice exhibiting megacolon with enteric ganglia, a phenotype associated in human with Intestinal Neuronal Dysplasia (IND). Using FISH and radiation hybrids we have localized HOX11L1 to human chromosome 2p13.1-->p12, in a 14-cR interval between WI-5987 (D2S2088) and GCT1B4 (D2S2497), and confirmed the synteny between mouse 6C3-D1 and human 2p13.1-->p12 chromosomes by mapping an EST cDNA clone corresponding to mouse HOX11L1 (Tlx2).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Banding
  • Chromosome Mapping
  • Chromosomes, Human, Pair 2 / genetics*
  • DNA Primers / genetics
  • Genes, Homeobox*
  • Humans
  • Hybrid Cells
  • In Situ Hybridization, Fluorescence
  • Intestines / innervation
  • Intestines / pathology
  • Mice / genetics*
  • Mice, Knockout
  • Phenotype
  • Species Specificity

Substances

  • DNA Primers

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