S1319: a novel beta2-andrenoceptor agonist from a marine sponge Dysidea sp

Bioorg Med Chem Lett. 1999 May 17;9(10):1361-4. doi: 10.1016/s0960-894x(99)00205-x.

Abstract

In the course of screening of potential leads for beta2-receptor agonists, we found a novel beta2-adrenoceptor selective agonist, S1319, from a marine sponge Dysidea sp. The active compound was isolated and structurally characterized as 4-hydroxy-7-[1-(1-hydroxy-2-methylamino)ethyl]-1,3-benzothiazole-2(3H)-o ne, a new member of the beta2-adrenoceptor agonist. This is the first example of a sponge-derived beta2-adrenoceptor agonist.

MeSH terms

  • Adrenergic beta-2 Receptor Agonists*
  • Adrenergic beta-Agonists / chemistry
  • Adrenergic beta-Agonists / isolation & purification*
  • Adrenergic beta-Agonists / metabolism
  • Animals
  • Benzothiazoles
  • Binding, Competitive
  • Ethanolamines / chemistry
  • Ethanolamines / isolation & purification*
  • Ethanolamines / metabolism
  • Guinea Pigs
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Muscle Relaxation / drug effects
  • Porifera / chemistry*
  • Propanolamines / metabolism
  • Receptors, Adrenergic, beta-2 / metabolism
  • Thiazoles / chemistry
  • Thiazoles / isolation & purification*
  • Thiazoles / metabolism
  • Trachea / drug effects
  • Trachea / physiology

Substances

  • 4-hydroxy-7-(1-(1-hydroxy-2-methylamino)ethyl)-1,3-benzothiazole-2(3H)-one
  • Adrenergic beta-2 Receptor Agonists
  • Adrenergic beta-Agonists
  • Benzothiazoles
  • Ethanolamines
  • Propanolamines
  • Receptors, Adrenergic, beta-2
  • Thiazoles
  • CGP 12177