Abstract
The relationships between acute myeloid leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic myeloid leukaemia (CML) and refractory anaemia with excess of blasts (RAEB) and human herpes virus (HHV)-6 antibody level were investigated in a multicentre case-control study. An association between increased HHV-6 seropositivity and geometric mean titre ratio with AML was shown: P for trend = 0.022, adjusted odds ratio 1.20, 95% confidence interval 1.07-1.33 respectively. No association was found between HHV-6 and ALL, CML or RAEB.
Publication types
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Clinical Trial
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Multicenter Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Anemia, Refractory, with Excess of Blasts / epidemiology*
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Anemia, Refractory, with Excess of Blasts / virology
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Antibodies, Viral / blood*
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Case-Control Studies
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Female
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Herpesvirus 6, Human / immunology*
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / epidemiology*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / virology
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Leukemia, Myeloid, Acute / epidemiology*
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Leukemia, Myeloid, Acute / virology
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Logistic Models
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Male
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Middle Aged
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Odds Ratio
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / virology
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Risk Factors
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Seroepidemiologic Studies