Transforming growth factor beta in infectious disease: always there for the host and the pathogen

D R Fitzpatrick; H Bielefeldt-Ohmann

doi:10.1016/s0966-842x(99)01498-5

Transforming growth factor beta in infectious disease: always there for the host and the pathogen

Trends Microbiol. 1999 Jun;7(6):232-6. doi: 10.1016/s0966-842x(99)01498-5.

Authors

D R Fitzpatrick¹, H Bielefeldt-Ohmann

Affiliation

¹ Leukocyte Biology Unit of the Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland 4029, Australia.

PMID: 10366859
DOI: 10.1016/s0966-842x(99)01498-5

Abstract

At the portals of pathogen entry, there are pools of the latent form of a potent cytokine, transforming growth factor beta (TGF-beta). Many infections activate these pools and stimulate further TGF-beta expression. As well as potent immunomodulation, activated TGF-beta might have important effects on pathogen entry, replication, persistence, latency and oncogenesis.

Publication types

Review

MeSH terms

Animals
Bacterial Infections / microbiology
Bacterial Infections / pathology
Chronic Disease
Communicable Diseases / microbiology
Communicable Diseases / pathology*
Disease Progression
Gene Expression Regulation*
Humans
Oncogenes
Parasitic Diseases / parasitology
Parasitic Diseases / pathology
Transforming Growth Factor beta / immunology
Transforming Growth Factor beta / physiology*

Substances

Transforming Growth Factor beta