Current source-density analysis of light-evoked field potentials in rabbit retina

Vis Neurosci. 1999 Mar-Apr;16(2):369-77. doi: 10.1017/s0952523899162163.

Abstract

The technique of current source-density analysis was applied to several components of the light-evoked field potentials (electroretinogram) from the retina of the superfused eyecup of rabbit. The depth distributions of the major current sources and sinks were: b-wave--sink at outer plexiform layer, source at inner plexiform layer; M-wave--sink at inner plexiform layer, source at retinal surface; and slow PIII--source near outer plexiform layer, sink at retinal surface. These distributions, along with the sensitivities of these responses to certain pharmacological agents, support earlier studies that Müller cells generate the M-wave and slow PIII, but that depolarizing bipolar cells directly generate the b-wave.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aminobutyrates / pharmacology
  • Animals
  • Barium Compounds / pharmacology
  • Chlorides / pharmacology
  • Electroretinography*
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology
  • Kynurenic Acid / pharmacology
  • Light
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Photic Stimulation
  • Picrotoxin / pharmacology
  • Rabbits
  • Retina / drug effects
  • Retina / physiology*

Substances

  • Aminobutyrates
  • Barium Compounds
  • Chlorides
  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • barium chloride
  • Picrotoxin
  • Kynurenic Acid
  • 2-amino-4-phosphonobutyric acid