Abstract
The diagnosis of secondary tumours represents one of the most important fields in the application of fine needle aspiration cytology (FNAC). We studied two patients, one with a history of breast cancer and one with a previous tumour of the thyroid, who showed a second mass, in the thyroid and in the breast, respectively, during follow up. The aim of our study was to evaluate if cytology, performed on FNAC smears, may distinguish a metastatic lesion from a second primary tumour, or if further immunocytochemistry should be performed. Our data demonstrate that, while cytology may be indicative of a second primary tumour, the histotype should be confirmed by immunocytochemical staining.
MeSH terms
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Aged
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Antibodies, Monoclonal / analysis
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Biopsy, Needle
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Breast Neoplasms / chemistry
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Breast Neoplasms / pathology*
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Carcinoma, Ductal, Breast / chemistry
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Carcinoma, Ductal, Breast / pathology*
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Carcinoma, Papillary / chemistry
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Carcinoma, Papillary / pathology*
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Diagnosis, Differential
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Female
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Fungal Proteins / analysis
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Humans
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Immunoenzyme Techniques
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Middle Aged
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Neoplasms, Second Primary / chemistry
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Neoplasms, Second Primary / pathology*
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Saccharomyces cerevisiae Proteins*
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Thyroglobulin / analysis
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Thyroid Neoplasms / chemistry
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Thyroid Neoplasms / pathology*
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Tumor Suppressor Protein p53 / analysis
Substances
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Antibodies, Monoclonal
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Fungal Proteins
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MBR1 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Tumor Suppressor Protein p53
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Thyroglobulin