Abstract
From the pro-inflammatory active extract of Euphorbia peplus, a new diterpene polyester (1) based on the jatrophane skeleton was isolated together with the known compounds 2-5. The irritant activities of some jatrophane diterpenes (2, 3 and 6-9) were also investigated: only compound 2 was found to exert a weak pro-inflammatory activity on mouse ear.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / toxicity
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Ear
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Irritants / chemistry*
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Irritants / isolation & purification
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Irritants / toxicity
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Mice
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / toxicity
Substances
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Diterpenes
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Irritants
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Plant Extracts