N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage

M Mattioli-Belmonte; A Gigante; R A Muzzarelli; R Politano; A De Benedittis; N Specchia; A Buffa; G Biagini; F Greco

doi:10.1007/BF02513279

N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage

Med Biol Eng Comput. 1999 Jan;37(1):130-4. doi: 10.1007/BF02513279.

Authors

M Mattioli-Belmonte¹, A Gigante, R A Muzzarelli, R Politano, A De Benedittis, N Specchia, A Buffa, G Biagini, F Greco

Affiliation

¹ Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Italy. [email protected]

PMID: 10396855
DOI: 10.1007/BF02513279

Abstract

Bone morphogenetic protein (BMP), associated with N,N-dicarboxymethyl chitosan, is used to induce or facilitate the repair of articular cartilage lesions. This association is intended for the synergistic potentiation of the respective biological effects. Data show that BMP-7 enhances the in vivo proliferation of cells with chondrocytes phenotype in the articular environment, leading to partial healing of the articular surface of the lesions. N,N-dicarboxymethyl chitosan is found to be useful as a molecular carrier or drug delivery agent.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins / administration & dosage*
Bone Morphogenetic Proteins / therapeutic use
Cartilage, Articular / drug effects
Cartilage, Articular / injuries*
Cartilage, Articular / pathology
Chitin / administration & dosage*
Chitin / analogs & derivatives
Drug Carriers
Male
Rabbits
Regeneration*
Transforming Growth Factor beta*

Substances

Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins
Drug Carriers
Transforming Growth Factor beta
Chitin