Chronic inflammatory demyelinating polyneuropathy with multiple hypertrophic nerves in intracranial, and intra- and extra-spinal segments

Intern Med. 1999 May;38(5):445-9. doi: 10.2169/internalmedicine.38.445.

Abstract

Hypertrophic nerves have occasionally been seen in chronic inflammatory demyelinating polyneuropathy (CIDP), but most are in the cauda equina. We report a case with CIDP in whom magnetic resonance imaging (MRI) with gadolinium diethylene triamine penta-acetic acid (Gd-DTPA) enhancement demonstrated hypertrophy of various peripheral nerves including multiple cranial nerves. Interestingly, none showed neurological signs corresponding to the lesions, except for clinical signs consistent with CIDP. MRI can be useful for the detection of silent, but abnormal nerve involvement in CIDP.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use
  • Chronic Disease
  • Cranial Nerves / drug effects
  • Cranial Nerves / pathology*
  • Demyelinating Diseases / complications*
  • Demyelinating Diseases / diagnosis
  • Gadolinium DTPA
  • Humans
  • Hypertrophy
  • Magnetic Resonance Imaging
  • Male
  • Peripheral Nervous System Diseases / complications*
  • Peripheral Nervous System Diseases / diagnosis
  • Peripheral Nervous System Diseases / drug therapy
  • Prednisolone / therapeutic use
  • Spinal Nerve Roots / drug effects
  • Spinal Nerve Roots / pathology*

Substances

  • Anti-Inflammatory Agents
  • Prednisolone
  • Gadolinium DTPA