Variant of the beta3-adrenergic receptor gene and coronary atherosclerosis in Japanese subjects

Int J Cardiol. 1999 Jun 1;69(3):309-11. doi: 10.1016/s0167-5273(99)00019-4.

Abstract

In the present study, we assessed the significance of the Trp64Arg mutation in the beta3-adrenergic receptor gene in 428 Japanese subjects, including 198 subjects who underwent coronary angiography for possible ischemic heart diseases (IHD group) and 230 non-IHD subjects (control group). We conclude that the Trp64Arg polymorphism of the beta3-adrenergic receptor gene did not appear to have any pathophysiological significance in Japanese subjects.

Publication types

  • Letter

MeSH terms

  • Arginine / genetics
  • Asian People / genetics*
  • Coronary Artery Disease / ethnology
  • Coronary Artery Disease / genetics*
  • Female
  • Genotype
  • Glucose Tolerance Test
  • Humans
  • Japan
  • Logistic Models
  • Male
  • Mutation, Missense
  • Polymorphism, Genetic*
  • Receptors, Adrenergic, beta / genetics*
  • Receptors, Adrenergic, beta-3
  • Tryptophan / genetics

Substances

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, beta-3
  • Tryptophan
  • Arginine