The effects of EMLA and a topical formulation of 4% amethocaine (Ametop) on pain associated with retrobulbar injection

Anaesthesia. 1999 Jun;54(6):596-8. doi: 10.1046/j.1365-2044.1999.00842.x.

Abstract

Retrobulbar block is commonly performed to provide anaesthesia for cataract extraction. This technique can cause significant discomfort. A prospective, randomised, placebo-controlled trial was carried out to investigate the efficacy of a eutectic mixture of local anaesthetics (EMLA) and a 4% amethocaine topical formulation (Ametop) in reducing the pain of retrobulbar injection. Ametop and EMLA proved to be of similar efficacy, both being superior to a placebo in alleviating the discomfort of retrobulbar block. No significant side-effects were observed with the use of either formulation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anesthesia, Local*
  • Anesthetics, Local*
  • Cataract Extraction*
  • Female
  • Humans
  • Injections / adverse effects*
  • Lidocaine*
  • Lidocaine, Prilocaine Drug Combination
  • Male
  • Middle Aged
  • Pain / prevention & control
  • Prilocaine*
  • Prospective Studies
  • Tetracaine*

Substances

  • Anesthetics, Local
  • Lidocaine, Prilocaine Drug Combination
  • Prilocaine
  • Tetracaine
  • Lidocaine