Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions

Brain Res. 1999 Jul 10;834(1-2):168-72. doi: 10.1016/s0006-8993(99)01487-0.

Abstract

We have previously shown that dopamine depletion reduces striatal damage elicited by the mitochondrial neurotoxins malonate and 3-nitropropionic acid (3NP). Metabolism of dopamine by monoamine oxidase results in the formation of hydrogen peroxide, which may mediate dopamine toxicity. In this study, administration of the monoamine oxidase inhibitors clorgyline and deprenyl resulted in a 42% and 75% reduction in lesion volumes in malonate- and 3NP-treated animals, respectively, compared to controls.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Clorgyline / pharmacology*
  • Corpus Striatum / drug effects*
  • Corpus Striatum / pathology*
  • Electron Transport Complex II
  • Male
  • Malonates / pharmacology*
  • Mitochondria / drug effects
  • Monoamine Oxidase Inhibitors / pharmacology*
  • Multienzyme Complexes / antagonists & inhibitors
  • Neurotoxins / pharmacology
  • Nitro Compounds
  • Oxidoreductases / antagonists & inhibitors
  • Propionates / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Selegiline / pharmacology*
  • Succinate Dehydrogenase / antagonists & inhibitors

Substances

  • Malonates
  • Monoamine Oxidase Inhibitors
  • Multienzyme Complexes
  • Neurotoxins
  • Nitro Compounds
  • Propionates
  • Selegiline
  • malonic acid
  • Oxidoreductases
  • Electron Transport Complex II
  • Succinate Dehydrogenase
  • Clorgyline
  • 3-nitropropionic acid