Cell polarity: Versatile scaffolds keep things in place

Curr Biol. 1999 Jul 15;9(14):R515-7. doi: 10.1016/s0960-9822(99)80324-8.

Abstract

Protein scaffolds organize transmembrane and cytoplasmic proteins and serve to integrate both structure and signaling at the apical junctional complex of polarized epithelial cells. These scaffolds are important in coordinating local and global changes in cell organization.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Cell Polarity*
  • Cytoplasm / physiology
  • Drosophila
  • Drosophila Proteins*
  • Epithelial Cells / physiology*
  • Insect Proteins / metabolism
  • Membrane Proteins / metabolism
  • Models, Biological
  • Mutation
  • Signal Transduction

Substances

  • Drosophila Proteins
  • Insect Proteins
  • Membrane Proteins
  • crb protein, Drosophila
  • dlt protein, Drosophila