Abstract
The goal of these studies was to analyze the ability of androstenediol (AED) to counter-regulate the influences of stress on anti-viral immune responses. Male C57BL/6 mice, treated with 320 mg/kg AED were infected with influenza virus and subjected to repeated cycles of restraint (RST). AED blocked RST-mediated suppression of cell recruitment to the draining lymph node, lung NK cell activity, and CD4 + T cell activation. In addition, mice treated with AED had lower pre-corticosterone levels as compared to vehicle controls and the RST-mediated elevation of corticosterone was significantly blunted by AED treatment. These data suggest that AED functions to augment anti-viral immune responses by counter-regulating glucocorticoid function.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anabolic Agents / pharmacology*
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Androstenediol / pharmacology*
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Animals
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Corticosterone / blood
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Cytotoxicity Tests, Immunologic
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Hypothalamo-Hypophyseal System / immunology
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Hypothalamo-Hypophyseal System / virology
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Immune Tolerance
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Influenza A virus / immunology*
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Interferon-gamma / immunology
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Interferon-gamma / metabolism
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Interleukin-10 / immunology
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Interleukin-10 / metabolism
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Killer Cells, Natural / immunology
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Killer Cells, Natural / virology
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Kinetics
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Leukocytes, Mononuclear / immunology
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Leukocytes, Mononuclear / metabolism
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Lymphatic Diseases / immunology
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Lymphatic Diseases / virology
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Male
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Mice
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Mice, Inbred C57BL
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Neurosecretory Systems / drug effects*
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Neurosecretory Systems / immunology*
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Neurosecretory Systems / virology
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Orthomyxoviridae Infections / immunology*
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Orthomyxoviridae Infections / mortality
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Pituitary-Adrenal System / immunology
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Pituitary-Adrenal System / virology
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Stress, Physiological / immunology
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Survival Analysis
Substances
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Anabolic Agents
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Interleukin-10
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Interferon-gamma
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Androstenediol
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Corticosterone