Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study

X de Leval; J M Dogné; P Neven; A Labasse; J Delarge; J Y Reginster; Y Henrotin

Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study

J Pharm Belg. 1999 May-Jun;54(3):89-90.

Authors

X de Leval¹, J M Dogné, P Neven, A Labasse, J Delarge, J Y Reginster, Y Henrotin

Affiliation

¹ Department of Medicinal Chemistry, C.H.U., University of Liège.

PMID: 10431478

Abstract

Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin.

MeSH terms

Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / pharmacology*
Indomethacin / pharmacology*
Isoenzymes / metabolism*
Prostaglandin-Endoperoxide Synthases / metabolism*
Substrate Specificity
Sulfonamides / pharmacology*

Substances

Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Isoenzymes
Sulfonamides
Cyclooxygenase 1
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
nimesulide
Indomethacin