Abstract
L-2'-Deoxy-2'-up-fluoro-4'-thionucleosides were efficiently synthesized from D-xylose via L-4-thioarabitol derivative as a key intermediate and evaluated for antiviral activities against HIV-1, HSV-1,2 and HBV.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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HIV-1 / drug effects
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Hepatitis B virus / drug effects
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Herpesvirus 1, Human / drug effects
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Herpesvirus 2, Human / drug effects
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Microbial Sensitivity Tests
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Thionucleosides / chemical synthesis*
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Thionucleosides / pharmacology*
Substances
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Antiviral Agents
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Thionucleosides