Abstract
Chemical and enzymatic methods were employed for the synthesis of the title compound, 2'F-Guo 7. High antiviral activity of 2'F-Guo was established in chick embryo cells infected with influenza virus FPV/Rostock/34 (H7N1) and herpes simplex virus (HSV) type I (1C strain).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Chick Embryo
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Deoxyguanosine / analogs & derivatives*
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Deoxyguanosine / chemical synthesis
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Deoxyguanosine / pharmacology
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Herpesvirus 1, Human / drug effects
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Orthomyxoviridae / drug effects
Substances
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Antiviral Agents
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2'-deoxy-2'-fluoroguanosine
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Deoxyguanosine