Synthesis of analogues of 5'-mono-, 5'-di-, and 5'-triphosphate-AZT for the development of specific enzyme immunoassay for monitoring of intracellular levels of AZT-MP, AZT-DP, and AZT-TP

T Brossette; M C Nevers; C Creminon; C Mioskowski; J Grassi; L Lebeau

doi:10.1080/15257779908041604

Synthesis of analogues of 5'-mono-, 5'-di-, and 5'-triphosphate-AZT for the development of specific enzyme immunoassay for monitoring of intracellular levels of AZT-MP, AZT-DP, and AZT-TP

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):939-40. doi: 10.1080/15257779908041604.

Authors

T Brossette¹, M C Nevers, C Creminon, C Mioskowski, J Grassi, L Lebeau

Affiliation

¹ Laboratoire de Synthèse Bioorganique associé au CNRS, Université Louis Pasteur, Faculté de pharmacie, Illkirch, France.

PMID: 10432713
DOI: 10.1080/15257779908041604

Abstract

The synthesis of analogue compounds of polyphosphorylated AZT is described. The compounds are designed to raise specific antibodies against AZT-MP, -DP and -TP in rabbits.

MeSH terms

Animals
Anti-HIV Agents / chemical synthesis
Anti-HIV Agents / metabolism
Immunoenzyme Techniques / methods
Phosphorylation
Rabbits
Zidovudine / analogs & derivatives*
Zidovudine / chemical synthesis
Zidovudine / metabolism

Substances

Anti-HIV Agents
Zidovudine