Abstract
A new antiviral drug with both anti-HSV and anti-HIV activity was synthesized by coupling Acyclovir and the acyclic nucleoside phosphonate (R)PMPA. The heterodinucleotide ACVpPMPA encapsulated into autologous erythrocytes was added to human macrophages providing an effective in vitro protection from HSV-1 and HIV-1 replication.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / pharmacology
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology
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Cells, Cultured
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HIV-1 / drug effects*
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Herpesvirus 1, Human / drug effects*
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Humans
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Macrophages / drug effects
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Macrophages / virology
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Microbial Sensitivity Tests
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Nucleosides / chemical synthesis*
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Nucleosides / pharmacology
Substances
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ACVpPMPA
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Anti-HIV Agents
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Antiviral Agents
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Nucleosides