Abstract
We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenal Glands / metabolism
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Adrenocorticotropic Hormone / pharmacology
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Aldosterone / biosynthesis
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Angiotensin II / pharmacology
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Corticosterone / biosynthesis*
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Desoxycorticosterone / analogs & derivatives*
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Desoxycorticosterone / biosynthesis*
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Humans
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Kinetics
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Melanoma / metabolism*
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Progesterone / metabolism*
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Skin / metabolism
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Tumor Cells, Cultured
Substances
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Angiotensin II
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18-hydroxydeoxycorticosterone
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Desoxycorticosterone
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Aldosterone
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Progesterone
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Adrenocorticotropic Hormone
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Corticosterone