Abstract
Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Actinomycetales / chemistry
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Actinomycetales / metabolism*
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Administration, Topical
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Animals
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / metabolism
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Anti-Inflammatory Agents / pharmacology*
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Ear Diseases / chemically induced
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Ear Diseases / drug therapy
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Edema / chemically induced
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Edema / drug therapy
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Fermentation
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Injections, Intraperitoneal
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / metabolism
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Macrolides / pharmacology*
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Tetradecanoylphorbol Acetate / toxicity
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Water Microbiology
Substances
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Anti-Inflammatory Agents
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Macrolides
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lobophorin A
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lobophorin B
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Tetradecanoylphorbol Acetate